CAS No. 27083-27-8
Biguanide 20, also known as Polyaminopropyl Biguanide (PABG), is a broad spectrum, fast acting bactericide. It is provided by the manufacturer as a 20% solution in water. A 20% aqueous solution of poly(hexamethylenebiguanide) hydrochloride, also known as PHMB, Polyaminopropyl Biguanide, used at an appropriate usage level (of 0.2 - 1.5%) is an effective preservative for make-up removers, moisturizing toners, facial cleansers, wet wipes and also offers antibacterial and deodorant properties. Originally formulated for the contact lens industry, it is also typically used in baby wipes. It is gentle in-use, with low eye and skin irritancy and low oral toxicity.
Biguanide 20 is an effective non-formaldehyde, non-paraben preservative with no VOCs (Volatile Organic Compounds) which is heat and UV stable. It is effective over a broad pH range (4-10), but most effective at a pH of 6.0 or less. As it is cationic, it is compatible with cationic, amphoteric and non-ionic surfactants. It is incompatible with strongly anionic systems.
Biguanide 20 is incompatible with natural liquid soaps and beeswax/borax emulsions. It is more compatible with cationic emulsifiers like Lotioncrafter BTMS. Polyaminopropyl Biguanide is not compatible with Xanthan Gum.
Biguanide 20 is heat stable to at least 80°C (176°F) and can be added pre or post emulsification. For complex formulations, consider combining with another preservative for a broader spectrum of activity or potassium sorbate for increased antifungal/mold protection.**
Recommended usage level: 0.2 - 1.5%.
Appearance: Clear to slightly pale yellow, slightly opalescent liquid.
pH: 5.0 - 5.5
Specific Gravity: 1.04
Solubility: Soluble in water. Miscible with ethanol, glycerin, and propylene glycol.
INCI: Polyaminopropyl Biguanide
Polyaminopropyl Biguanide
Although a synthetic ingredient, it is not a terribly dangerous one. It is not known to be mutagenic on mamilian cells, not an endocrine disruptor, not carcinogenic, and has a low toxicity. It is not easily absorbed in to skin, and pretty mild on skin and eyes. One fact that gives me pause is the way in which it works--by breaking the cell wall of the bacteria and damaging its DNA. Anything that damages DNA doesn't sound very good to me. However, the studies that have been done on the ingredient have shown that it's not strong enough to break down mamilian cells--so that's a good thing. The bottom line: although it's not a natural ingredient that I would personally use, if you have to use it (say, in your contact solution) you can breathe a little sigh of relief that it's a safer ingredient.
Cosmocil CQ
Cosmocil CQ is a really novel preservative, relying upon polyhexamethylene biguanide (PHMB) as the preservative, which is neither a formaldehyde releaser nor a paraben based product. The INCI is polyaminopropyl biguanide. It's both a bacteriostatic and bactericidal preservative that should be combined with a fungicide like one of the parabens, potassium sorbate, or sodium benzoate (one of the organic acids).
It's cationic and the manufacturer notes it is incompatible with what they call strongly anionic systems, so I'd be careful using it with shampoo, body wash, and other foamy surfactant mixes. It is effective for pH 4 to 10, so you can use it with pretty much any product we make, with the ideal being below 6. It's soluble in water, ethanol, glycerin, and propylene glycol but insoluble in vegetable and mineral oils and esters, so you'll want to use in products that contain water. You can use it in your creations in the water phase while you heat it or add it just before emulsification. (One data sheet says it's heat stable to 140˚C, but when do we ever reach those temperatures? So I'm going with the stable to 80˚C suggestion.) The most frequent suggestion is that we should add it to the water phase before heating.
Summary of Cosmocil CQ
INCI: Polyaminopropyl biguanide
Usage: From 0.05% to 1.5%. Approved at up to 1.5% in the EU and 0.5% in Japan.
Not suitable for anhydrous products. Add in the heated water phase of your products pre- or post-emulsification.
Suitable for products with pH 4 to 10.
I tried Cosmocil at .7%, with .14% potassium sorbate and .115% citric acid, as per one suggested use in this pdf, but my formulation didn't hold up for even a couple of weeks. I didn't realise it had to be used in the heated phase though, so maybe that was a factor. I tried it again at 1% with .2% potassium sorbate in a deodorant, and so far (a few weeks in), it's holding up much better.
I've used since May w/ max plus k sorbate max. In addition 1% lavender essential oil, 4% ethanol. Dunno if it would be as good w/o the extras though, but so far, clean as a whistle in my normal usage- jar w/ fingers daily in it. I have 3 very close friends using lotion with same formulation in pump bottle last 9 wks also. Good feedback so far. No fur, smell, or any other funkiness. OH!! it was 65% oil phase too! So can't say w/ more water phase. Gonna formulate with 75% water phase. Gonna push it to it's max with etracts, aloe, and hydrosols!!!!!!!!!! Will see next few weeks if it can tolerate all the fresh bug food!
Beware Cosmocil CQ
According to http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33978
Cosmocil CQ is a "possible" carcinogen.
I kid you not. It is there.
And here's more from a typical MSDS for this pretender:
"Polyaminopropyl Biguanide, the biocidal active in this product, has been extensively studied for its toxicity to mammalian systems. Repeated inhalation exposure in rats over a period of 4 weeks resulted in eye and respiratory irritation and pneumonitis. Long term feeding studies in dogs show that the liver and kidney are target organs and the effect occur but only at very high doses. Polyaminopropyl Biguanide has been shown in animal studies to produce skin sensitization."
댓글 없음:
댓글 쓰기